What is the new sweetener hesperidin

Naringenin  in 7 carbon position and new hesperidose into glycosides, called naringenin, taste extremely bitter. It is a sweetener with a sweetness up to 2 000 times that of sucrose when the ring is opened and hydrogenated to form dihydrochalcone compounds under alkaline conditions. Hesperidin exists in large quantities in citrus peel.

Hesperidin forms glycosides with rutin at 7 carbon position, which is called neohesperidin, and β-neohesperidin forms glycosides at 7 carbon position.

 (4) Cardiovascular protection: hesperidin has the effect of reducing blood fat and vascular permeability, and can prevent thrombosis. Hesperidin can also protect endothelial cells from hypoxia by stimulating certain mitochondrial enzymes such as succinate dehydrogenase and prevent thrombus formation induced by clotting caused by endothelial cell necrosis. In addition, hesperidin promotes antiplatelet clotting activity by inhibiting the phosphorylation of PLCγ2 and its downstream signaling, which can prevent the formation of thrombus and is beneficial to the cardiovascular system. (5) Anti-tumor effect: hesperidin has antioxidant effect, which can avoid the cancer caused by genetic changes caused by these factors. Promote the flow of P-glycoprotein-mediated drugs from tumor cells, and flavonoids (hesperidin, etc.) can change the blood-brain barrier permeability to vincristine, which is also related to its concentration. Low concentration of flavonoids can reduce the uptake of vincristine by brain capillary endothelial cells. On the contrary, high concentration has a promoting effect.

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